| Autor: |
Tatjana Wallmann, Xing-Mei Zhang, Majken Wallerius, Sara Bolin, Anne-Laure Joly, Caroline Sobocki, Lina Leiss, Yiwen Jiang, Jonas Bergh, Eric C. Holland, Per Ø. Enger, John Andersson, Fredrik J. Swartling, Hrvoje Miletic, Lene Uhrbom, Robert A. Harris, Charlotte Rolny |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
iScience, Vol 9, Iss , Pp 71-83 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2018.10.011 |
| Popis: |
Summary: High-grade gliomas (HGGs) are the most aggressive and invasive primary brain tumors. The platelet-derived growth factor (PDGF) signaling pathway drives HGG progression, and enhanced expression of PDGF receptors (PDGFRs) is a well-established aberration in a subset of glioblastomas (GBMs). PDGFRA is expressed in glioma cells, whereas PDGFRB is mostly restricted to the glioma-associated stroma. Here we show that the spatial location of TAMMs correlates with the expansion of a subset of tumor cells that have acquired expression of PDGFRB in both mouse and human low-grade glioma and HCGs. Furthermore, M2-polarized microglia but not bone marrow (BM)-derived macrophages (BMDMs) induced PDGFRB expression in glioma cells and stimulated their migratory capacity. These findings illustrate a heterotypic cross-talk between microglia and glioma cells that may enhance the migratory and invasive capacity of the latter by inducing PDGFRB. : Pathophysiology; Molecular Mechanism of Behavior; Immunology; Cancer Subject Areas: Pathophysiology, Molecular Mechanism of Behavior, Immunology, Cancer |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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