An in vitro culture platform for studying the effect of collective cell migration on spatial self-organization within induced pluripotent stem cell colonies

Autor:	Mee-Hae Kim, Masaki Kuroda, Ding Ke, Naruchit Thanuthanakhun, Masahiro Kino-oka
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Human induced pluripotent stem cells Ring culture system Actin actomyosin Collective cell migration Epithelial mesenchymal transition Mesendoderm lineage segregation Biology (General) QH301-705.5
Zdroj:	Journal of Biological Engineering, Vol 17, Iss 1, Pp 1-16 (2023)
Druh dokumentu:	article
ISSN:	1754-1611
DOI:	10.1186/s13036-023-00341-z
Popis:	Highlights • Ring culture system induces distinct changes in actomyosin organization at the iPSC colony edge. • Removal of ring culture system induces collective cell migration at the iPSC colony edge. • Collective cell migration modulates self-organized fate patterning decisions in iPSC-derived gastrulation-stage meso–endoderm. • Cadherin switching during collective cell migration enhances endodermal differentiation.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/8c2ff219271244fd8a91336bc8a159be Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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