Impact of aetiological treatment on conventional and multiplex serology in chronic Chagas disease.
| Autor: | Rodolfo Viotti, Carlos Vigliano, María Gabriela Alvarez, Bruno Lococo, Marcos Petti, Graciela Bertocchi, Alejandro Armenti, Ana María De Rissio, Gretchen Cooley, Rick Tarleton, Susana Laucella |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | PLoS Neglected Tropical Diseases, Vol 5, Iss 9, p e1314 (2011) |
| Druh dokumentu: | article |
| ISSN: | 1935-2727 1935-2735 |
| DOI: | 10.1371/journal.pntd.0001314 |
| Popis: | The main criterion for treatment effectiveness in Chagas Disease has been the seronegative conversion, achieved many years post-treatment. One of the main limitations in evaluating treatment for chronic Chagas disease is the lack of reliable tests to ensure parasite clearance and to examine the effects of treatment. However, declines in conventional serological titers and a new multiplex assay can be useful tools to monitor early the treatment impact.Changes in antibody levels, including seronegative conversion as well as declines in titers, were serially measured in 53 benznidazole-treated and 89 untreated chronic patients in Buenos Aires, Argentina with a median follow-up of 36 months. Decrease of titers (34/53 [64%] treated vs. 19/89 [21%] untreated, p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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