| Autor: |
Wesley M. Botello-Smith, Wenjuan Jiang, Han Zhang, Alper D. Ozkan, Yi-Chun Lin, Christine N. Pham, Jérôme J. Lacroix, Yun Luo |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-019-12501-1 |
| Popis: |
Besides mechanical forces, the mechanosensitive channel Piezo1 is activated by the small molecule Yoda1 through an unknown mechanism. Here, using molecular dynamics simulations, calcium imaging and electrophysiology, the authors identify an allosteric Yoda1 binding pocket located in the putative mechanosensory domain. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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