Synthesis and Biological Activities of Dehydrodiisoeugenol: A Review

Autor: Beatriz Godínez-Chaparro, Salud Pérez-Gutiérrez, Julia Pérez-Ramos, Ivo Heyerdahl-Viau, Liliana Hernández-Vázquez
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Pharmaceuticals, Vol 15, Iss 11, p 1351 (2022)
Druh dokumentu: article
ISSN: 1424-8247
DOI: 10.3390/ph15111351
Popis: Dehydrodiisoeugenol (DHIE) is a neolignan found in more than 17 plant species, including herbs, fruit, and root. DHIE was, for the first time, isolated from Myristica fragrans bark in 1973. Since then, many methodologies have been used for the obtention of DHIE, including classical chemistry synthesis using metal catalysts and biocatalytic synthesis; employing horseradish peroxidase; peroxidase from Cocos nucifera; laccase; culture cells of plants; and microorganisms. Increasing evidence has indicated that DHIE has a wide range of biological activities: anti-inflammatory, anti-oxidant, anti-cancerogenic, and anti-microbial properties. However, evidence in vivo and in human beings is still lacking to support the usefulness potential of DHIE as a therapeutic agent. This study’s review was created by searching for relevant DHIE material on websites such as Google Scholar, PubMed, SciFinder, Scholar, Science Direct, and others. This reviews the current state of knowledge regarding the different synthetical routes and biological applications of DHIE.
Databáze: Directory of Open Access Journals
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