Synthesis of 4-Hydroxy-2-Methylchalcone from meta-Cresol Formilation Product and Its Activities as an Antibacteria
| Autor: | Ismiyarto Ismiyarto, Suyanti Suyanti, Ngadiwiyana Ngadiwiyana, Purbowatiningrum Ria Sarjono, Nor Basid Adiwibawa Prasetya |
|---|---|
| Jazyk: | English<br />Indonesian |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Jurnal Kimia Sains dan Aplikasi, Vol 21, Iss 4, Pp 193-197 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1410-8917 2597-9914 |
| DOI: | 10.14710/jksa.21.4.193-197 |
| Popis: | Research on the synthesis of 4-hydroxy-2-methylchalcone from 4-hidroksi-2-metilbenzaldehida as formilated meta-cresol product and its antibacterial activity test has been conducted. As the first step, synthesis of 4-hydroxy-2-methylbenzaldehyde was carried out by treatment meta-cresol with chloroform through the Reimer-Tiemann formylation. Product is a brown solid with 23.94% yields. Furthermore, the 4-hydroxy-2-methylchalcone was synthesized using the 4-hydroxy-2-methylbenzaldehyde and acetophenone through the Claisen-Schmidt reaction. The product is a brownish yellow solid with 29.74% yields. Antibacterial test against Escherichia coli and Staphylococcus aureus bacteria was carried out by comparing the activity of 4-hydroxy-2-methylchalcone with 4-hydroxy-3-methoxychalcone, and chalcone compounds. The antibacterial activity test showed that the 4-hydroxy-2-methylchalcone compound, 4-hydroxy-3-methoxychalcone, and chalcone compounds gave a better antibacterial activity against Escherichia coli than the Staphylococcus aureus. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|