Mast Cells and Natural Killer Cells—A Potentially Critical Interaction

Autor:	Liliana Portales-Cervantes, Bassel Dawod, Jean S. Marshall
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	mast cells NK cells cytokines CXCL8 interferons cell recruitment cellular activation oncolytic virus Microbiology QR1-502
Zdroj:	Viruses, Vol 11, Iss 6, p 514 (2019)
Druh dokumentu:	article
ISSN:	1999-4915 11060514
DOI:	10.3390/v11060514
Popis:	Natural killer (NK) cells play critical roles in host defense against infectious agents or neoplastic cells. NK cells provide a rapid innate immune response including the killing of target cells without the need for priming. However, activated NK cells can show improved effector functions. Mast cells are also critical for early host defense against a variety of pathogens and are predominately located at mucosal surfaces and close to blood vessels. Our group has recently shown that virus-infected mast cells selectively recruit NK cells and positively modulate their functions through mechanisms dependent on soluble mediators, such as interferons. Here, we review the possible consequences of this interaction in both host defense and pathologies involving NK cell and mast cell activation.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c8c09c46fe744c0c85acd57f78c0a74c Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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