Soluble Flt1 levels are associated with cardiac dysfunction in Black women with and without severe preeclampsia

Autor:	Lisa Levine, Zolt Arany, Adina Kern-Goldberger, Nathanael Koelper, Jennifer Lewey, Mary D. Sammel, Michal A. Elovitz, Bonnie Ky
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	black women cardiac function echocardiogram longitudinal strain preeclampsia soluble flt Gynecology and obstetrics RG1-991
Zdroj:	Hypertension in Pregnancy, Vol 40, Iss 1, Pp 44-49 (2021)
Druh dokumentu:	article
ISSN:	1064-1955 1525-6065 10641955
DOI:	10.1080/10641955.2020.1861462
Popis:	Background: We evaluate soluble fms-like tyrosine kinase-1 (sFlt-1) levels and cardiac function during pregnancy and postpartum among Black women with and without preeclampsia. Study design: Prospective longitudinal cohort study from 2015 to 2017 of Black women with preterm severe preeclampsia and normotensive pregnant controls.We obtained echocardiograms and sFlt-1 levels during pregnancy and postpartum. Results: 93 Black women were included (43 cases, 50 controls). Higher sFlt1 levels were correlated with worse longitudinal strain, diastolic dysfunction, decreased ventricular-arterial coupling, and increased chamber and arterial elastance at the time of preeclampsia diagnosis and postpartum. Conclusions: Higher sFlt1 levels are associated with cardiovascular dysfunction during pregnancy and postpartum.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/8c0271279790474ead484d9a1512241b Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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