Soluble Flt1 levels are associated with cardiac dysfunction in Black women with and without severe preeclampsia
Autor: | Lisa Levine, Zolt Arany, Adina Kern-Goldberger, Nathanael Koelper, Jennifer Lewey, Mary D. Sammel, Michal A. Elovitz, Bonnie Ky |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: | |
Zdroj: | Hypertension in Pregnancy, Vol 40, Iss 1, Pp 44-49 (2021) |
Druh dokumentu: | article |
ISSN: | 1064-1955 1525-6065 10641955 |
DOI: | 10.1080/10641955.2020.1861462 |
Popis: | Background: We evaluate soluble fms-like tyrosine kinase-1 (sFlt-1) levels and cardiac function during pregnancy and postpartum among Black women with and without preeclampsia. Study design: Prospective longitudinal cohort study from 2015 to 2017 of Black women with preterm severe preeclampsia and normotensive pregnant controls.We obtained echocardiograms and sFlt-1 levels during pregnancy and postpartum. Results: 93 Black women were included (43 cases, 50 controls). Higher sFlt1 levels were correlated with worse longitudinal strain, diastolic dysfunction, decreased ventricular-arterial coupling, and increased chamber and arterial elastance at the time of preeclampsia diagnosis and postpartum. Conclusions: Higher sFlt1 levels are associated with cardiovascular dysfunction during pregnancy and postpartum. |
Databáze: | Directory of Open Access Journals |
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