Anti-metastatic Activity of Curcumin Analog Pentagamaboronon-0-Sorbitol Against HER2-overexpressed MCF-7 Breast Cancer Cells
| Autor: | Lailatul Qodria, Indah Hairunisa, Rohmad Yudi Utomo, Adam Hermawan, Edy Meiyanto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | ISCC (Indonesian Journal of Cancer Chemoprevention), Vol 9, Iss 3, Pp 118-125 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2088-0197 2355-8989 |
| DOI: | 10.14499/indonesianjcanchemoprev9iss3pp118-125 |
| Popis: | Breast cancer with Human Epidermal Growth Factor Receptor (HER)2 overexpression increases tumor progession and lead to metastasis, which is primarily cause of mortality in breast cancer. Pentagamaboronon-0 Sorbitol (PGB-0-So) is an aquoeous formulation of curcumin analog, PGB-0, with sorbitol. This compound has been developed as an anti-cancer chemotherapeutic agent and a boron carrying pharmaceutical for boron neutron capture therapy (BNCT). The aims of this study are to investigate antimetastatic activities of PGB-0-So against HER2-overexpressed MCF-7 breast cancer (MCF-7/HER2) cells. The MTT cytotoxicity assay of PGB-0-So exhibited cytotoxic effect with an IC50 value of 35 μM. The testing of anti-migration activity using the scratch wound healing assay demonstrated that PGB-0-So inhibited the closure of the wound on MCF-7/HER2 cells compare to the control. Furthermore, PGB-0-So was able to suppress matrix metalloproteinase (MMP)-9 activities, based on the gelatin zymography assay. In conclusion, PGB-0-So has potency to be developed as an anti-cancer agent against metastatic breast cancer. Keywords : PGB-0-So, anti-metastatsis, cell migration, MMP-9, MCF-7/HER2 |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|