Hypoxia-induced pulmonary vasoconstriction of intra-acinar arteries is impaired in NADPH oxidase 4 gene-deficient mice

Autor:	Ghulam Murtaza, Renate Paddenberg, Uwe Pfeil, Anna Goldenberg, Petra Mermer, Wolfgang Kummer
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the respiratory system RC705-779
Zdroj:	Pulmonary Circulation, Vol 8 (2018)
Druh dokumentu:	article
ISSN:	2045-8940 20458940
DOI:	10.1177/2045894018808240
Popis:	We show that genetic deficiency of the reactive oxygen species generating enzyme NADPH oxidase 4 (NOX4) impairs hypoxic pulmonary vasoconstriction in small (25–40 µm) intra-acinar, but not pre-acinar, arteries in murine precision cut lung slices. These data suggest an involvement of NOX4 in ventilation-perfusion matching at the acinar level.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/8bed3083588f47538107238a87d68b2f Zobrazit plný text záznamu Plný text View record in DOAJ