Familial Myelodysplastic/Acute Leukemia Syndromes—Myeloid Neoplasms with Germline Predisposition

Autor: Renata Lyrio Rafael Baptista, Anna Cláudia Evangelista dos Santos, Luciana Mayumi Gutiyama, Cristiana Solza, Ilana Renault Zalcberg
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Frontiers in Oncology, Vol 7 (2017)
Druh dokumentu: article
ISSN: 2234-943X
DOI: 10.3389/fonc.2017.00206
Popis: Although most cases of myeloid neoplasms are sporadic, a small subset has been associated with germline mutations. The 2016 revision of the World Health Organization classification included these cases in a myeloid neoplasm group with a predisposing germline mutational background. These patients must have a different management and their families should get genetic counseling. Cases identification and outline of the major known syndromes characteristics will be discussed in this text.
Databáze: Directory of Open Access Journals