Effectiveness of thiamphenicol glycinate acetilcysteinate in inhalation treatment of children with rhinosinusitis
| Autor: | M. R. Bogomilskiy, E. Yu. Radtsig, N. D. Pivneva, V. E. Kuyanova |
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| Jazyk: | ruština |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Rossijskij Vestnik Perinatologii i Pediatrii, Vol 66, Iss 1, Pp 73-79 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1027-4065 2500-2228 81554133 |
| DOI: | 10.21508/1027-4065-2021-66-1-73-79 |
| Popis: | The article evaluates the effectiveness of thiamphenicol glycinate acetylcysteinate for inhalation versus systemic antibiotic for oral administration in complex treatment of uncomplicated rhinosinusitis in the outpatient conditions.Characteristics of children and research methods. The prospective, single-center, randomized, pilot, open-label comparative study included 61 patients from 3 to 9 years old with acute rhinosinusitis meeting the inclusion criteria. Group 1: children were prescribed thiamphenicol glycinate acetylcysteinate (0.125 mg per inhalation twice a day), Group 2: patients received amoxicillin clavulanate at an age-specific dosage of 40-45 mg/kg orally 2 or 3 times a day. At each visit (Day 0 and Day 7–8) the scientists assessed such symptoms as nasal breathing and rhinoscopy findings (edema, hyperemia of the mucous membrane and nasal discharge) on a 10-point visual analogue scale. At the repeated examination (Day 7-8), they assessed the effectiveness of the treatment (recovery/improvement/cure), the duration of treatment (in days) and the number of drugs taken simultaneously, as well as the tolerability of treatment by the presence/absence of undesirable or side effects. The Python language (Python 3.8.) was used for statistical processing of the obtained data. They used the built-in functions from the Scipy module for calculation.Results. At the time of inclusion in the study (Day 0), the condition of the patients in both groups was comparable (p>0.05). When comparing condition of the patients on Day 0 and Day 7-8 there was a therapeutic effect in both groups for all studied symptoms (p |
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