| Autor: |
Mauro F. F. Mediano, Leonardo G. Ribeiro, Rudson S. Silva, Isis G. G. Xavier, Marcelo C. Vieira, Tatiana R. Gonçalves, Vitor B. Paravidino, Juliana P. Borges, Luiz Fernando Rodrigues Junior, Henrique S. Costa, Michel S. Reis, Livia C. Liporagi-Lopes, Pablo Martinez-Amezcua, Paula S. Silva, Gilberto M. Sperandio Da Silva, Andrea S. Sousa, Marcelo T. Holanda, Henrique H. Veloso, Fernanda M. Carneiro, Flavia Mazzoli-Rocha, Andrea R. Costa, Roberto M. Saraiva, Fernanda S. N. S. Mendes, Luiz Henrique C. Sangenis, Alejandro M. Hasslocher-Moreno |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Frontiers in Medicine, Vol 9 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2296-858X |
| DOI: |
10.3389/fmed.2022.1087188 |
| Popis: |
BackgroundChagas disease (CD) is a neglected endemic disease with worldwide impact due to migration. Approximately 50–70% of individuals in the chronic phase of CD present the indeterminate form, characterized by parasitological and/or serological evidence of Trypanosoma cruzi infection, but without clinical signs and symptoms. Subclinical abnormalities have been reported in indeterminate form of CD, including pro-inflammatory states and alterations in cardiac function, biomarkers and autonomic modulation. Moreover, individuals with CD are usually impacted on their personal and professional life, making social insertion difficult and impacting their mental health and quality of life (QoL). Physical exercise has been acknowledged as an important strategy to prevent and control numerous chronic-degenerative diseases, but unexplored in individuals with the indeterminate form of CD. The PEDI-CHAGAS study (which stands for “Home-Based Exercise Program in the Indeterminate Form of Chagas Disease” in Portuguese) aims to evaluate the effects of a home-based exercise program on physical and mental health outcomes in individuals with indeterminate form of CD.Methods and designThe PEDI-CHAGAS is a two-arm (exercise and control) phase 3 superiority randomized clinical trial including patients with indeterminate form of CD. The exclusion criteria are |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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