Exposure to polybrominated biphenyl (PBB) associates with genome-wide DNA methylation differences in peripheral blood

Autor:	Sarah W. Curtis, Dawayland O. Cobb, Varun Kilaru, Metrecia L. Terrell, Elizabeth M. Kennedy, M. Elizabeth Marder, Dana Boyd Barr, Carmen J. Marsit, Michele Marcus, Karen N. Conneely, Alicia K. Smith
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	endocrine-disrupting compound epigenome-wide association study (ewas) dna methylation polybrominated biphenyl environmental health epigenetics Genetics QH426-470
Zdroj:	Epigenetics, Vol 14, Iss 1, Pp 52-66 (2019)
Druh dokumentu:	article
ISSN:	1559-2294 1559-2308 15592294
DOI:	10.1080/15592294.2019.1565590
Popis:	In 1973, Michigan residents were exposed to polybrominated biphenyl (PBB) when it was accidentally added to farm animal feed. Highly exposed individuals and their children have experienced endocrine-related health problems, though the underlying mechanism behind these remains unknown. We investigated whether PBB exposure is associated with variation in DNA methylation in peripheral blood samples from 658 participants of the Michigan PBB registry using the MethylationEPIC BeadChip, as well as investigated what the potential function of the affected regions are and whether these epigenetic marks are known to associate with endocrine system pathways. After multiple test correction (FDR
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/8bd8b11744b64ac2a0ecb0714e1496db Zobrazit plný text záznamu View record in DOAJ