Structural basis for broad anti-phage immunity by DISARM

Autor: Jack P. K. Bravo, Cristian Aparicio-Maldonado, Franklin L. Nobrega, Stan J. J. Brouns, David W. Taylor
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-30673-1
Popis: DISARM (Defense Island System Associated with Restriction Modification) systems can provide bacteria with protection against a wide range of phage. Here, Bravo et al. determine cryo-EM structures of the core DISARM complex that shed light onto phage DNA recognition and activation of this widespread defense system.
Databáze: Directory of Open Access Journals