| Autor: |
Chokchai Chuangchot, Unchalee Tattawasart, Bungorn Sripanidkulchai, Jintana Junlatat, Niramai Fangkrathok |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Songklanakarin Journal of Science and Technology (SJST), Vol 39, Iss 2, Pp 163-170 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
0125-3395 |
| DOI: |
10.14456/sjst-psu.2017.19 |
| Popis: |
Rafflesia kerrii (RK) has been used as a folk medicine for the treatment of many diseases. Bactericidal activity of its ethanol extract against multidrug-resistant (MDR) bacteria including methicillin resistant Staphylococcus aureus (MRSA), Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia was investigated using the microbroth dilution method and time-kill assay. Results showed broad spectrum antibacterial activity against all test bacteria with minimum bactericidal concentrations (MBCs) in the range of 0.78 to 6.25 mg/ml. The extract with a concentration of 2xMBC completely killed the MRSA after 24 h-exposure, whereas it completely killed A. baumannii, P. aeruginosa and S. maltophilia after 3 h-exposure. It contained a high total phenolic content (669.66±38.60 mg TAE/g) and exhibited stronger antioxidant activity than the ascorbic acid standard (EC50 at 1.79±0.02 µg/ml). These results indicate that the RK extract is a potential candidate to be used as an antioxidant and antibacterial agent for MDR bacteria. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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