Relationship of liver fat content with systemic metabolism and chronic complications in patients with type 2 diabetes mellitus

Autor: Weiwei Ren, Yunlu Feng, Youzhen Feng, Jiaying Li, Chuangbiao Zhang, Lie Feng, Lijuan Cui, Jianmin Ran
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Lipids in Health and Disease, Vol 22, Iss 1, Pp 1-9 (2023)
Druh dokumentu: article
ISSN: 1476-511X
DOI: 10.1186/s12944-023-01775-6
Popis: Abstract Objective This study investigated the correlation of liver fat content (LFC) with metabolic characteristics and its association with chronic complications in type 2 diabetes mellitus (T2DM) patients. Methods Eighty-one prospectively enrolled T2DM patients were divided into non-alcoholic fatty liver disease (NAFLD) group and the non-NAFLD group according to the presence of NAFL complications. LFC was determined by MRI IDEAL-IQ Sequence, and patients were divided into 4 groups according to LFC by quartile method. Basic information, metabolic indexes, and occurrence of chronic complications in different groups were analyzed and compared. Results BMI, SBP, DBP, TG, ALT, AST, GGT, UA, HbA1c, FCP, 2 h CP, HOMA-IR, and HOMA-IS in the NAFLD group were significantly higher than the non-NAFLD group (P 0.05). BMI, SBP, DBP, TC, TG, ALT, AST, FCP, 2 h CP, HOMA-IR, and HOMA-IS showed significant differences between the patients with different LFC, and these indexes were significantly higher in patients with higher LFC than those with lower LFC (P
Databáze: Directory of Open Access Journals
Nepřihlášeným uživatelům se plný text nezobrazuje