Gamma-Glutamyl Transferase and the Risk of Type 2 Diabetes Mellitus: A Review
| Autor: | Sachini M Thennakoon, Niroshima D Withanage |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Iranian Journal of Diabetes and Obesity, Vol 15, Iss 4, Pp 243-255 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2008-6792 2345-2250 |
| Popis: | The relationship between gamma-glutamyl transferase (GGT) levels and risk factors for type 2 diabetes mellitus (T2DM) and the risk of incident T2DM was assessed using a narrative review of available evidence. Higher circulating levels of GGT are associated with an increased risk of type 2 diabetes mellitus, suggesting GGT as a risk predictor of T2DM. The incidence of type 2 diabetes and its association with GGT elevation could be explained by oxidative stress in cells followed by subclinical inflammation and fatty liver, leading to impaired insulin secretion and insulin resistance. A strong correlation is evident between BMI and GGT, in which hepatic steatosis and insulin resistance are proposed to be the intermediate connecting characteristics. |
| Databáze: | Directory of Open Access Journals |
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