Cangrelor ameliorates CLP-induced pulmonary injury in sepsis by inhibiting GPR17

Autor: Qiancheng Luo, Rui Liu, Kaili Qu, Guorong Liu, Min Hang, Guo Chen, Lei Xu, Qinqin Jin, Dongfeng Guo, Qi Kang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: European Journal of Medical Research, Vol 26, Iss 1, Pp 1-7 (2021)
Druh dokumentu: article
ISSN: 2047-783X
46813292
DOI: 10.1186/s40001-021-00536-4
Popis: Abstract Background Sepsis is a common complication of severe wound injury and infection, with a very high mortality rate. The P2Y12 receptor inhibitor, cangrelor, is an antagonist anti-platelet drug. Methods In our study, we investigated the protective mechanisms of cangrelor in CLP-induced pulmonary injury in sepsis, using C57BL/6 mouse models. Results TdT-mediated dUTP Nick-End Labeling (TUNEL) and Masson staining showed that apoptosis and fibrosis in lungs were alleviated by cangrelor treatment. Cangrelor significantly promoted surface expression of CD40L on platelets and inhibited CLP-induced neutrophils in Bronchoalveolar lavage fluid (BALF) (p
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