| Autor: |
Teresa Pinheiro, Luís C. Alves, Victoria Corregidor, Francesc Teixidor, Clara Viñas, Fernanda Marques |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
EPJ Techniques and Instrumentation, Vol 10, Iss 1, Pp 1-8 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2195-7045 |
| DOI: |
10.1140/epjti/s40485-023-00093-6 |
| Popis: |
Abstract The feasibility of using an external beam microprobe facility to explore the biological effects generated by proton irradiation in cultured cells is demonstrated. An in-air irradiation set-up was developed that allows energy tuning and enables estimating the flux and dose deposition in cells. A pilot study on the effect of boron-rich metallacarboranes as radiosensitizers towards human glioblastoma cells was carried out. This served as a proof of concept for the enhancement effect of proton irradiation induced by the presence of boron, which undergoes a nuclear 11B(p,α)αα reaction. Details of the experimental set-up and physical parameters measured are presented. Also, preliminary results of cell’s irradiation and uncertainties are discussed anticipating the advances that have been achieved by our group in this field. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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