Fasting Plasma Glucose Indicates Reversibility of the Acute Insulin Response after Short-Term Intensive Insulin Therapy in Patients with Various Duration of Type 2 Diabetes

Autor: Liehua Liu, Siyue Yang, Jianbin Liu, Hai Li, Juan Liu, Xiaopei Cao, Haipeng Xiao, Yanbing Li
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Journal of Diabetes Research, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 2314-6745
2314-6753
DOI: 10.1155/2018/9423965
Popis: Recovery of acute insulin response (AIR) is shown to be associated with long-term outcomes of patients with early type 2 diabetes treated with short-term intensive insulin therapy (SIIT). However, the complexity of measuring an AIR limits its utility in a real-world clinical setting. The aim of the study was to assess fasting indicators that may estimate recovery of the AIR after SIIT. We enrolled 62 patients with type 2 diabetes mellitus (T2DM) of varying disease duration who had poor glycemic control. Participants were treated with SIIT using insulin pumps to achieve near normoglycemia for 7 days. The AIR before and after the therapy were measured by intravenous glucose tolerance tests. After the therapy, AIR increased from −16.7 (−117.4, 52.4) pmol/L·min to 178.7 (31.8, 390.7) pmol/L·min (P 10 mmol/L, while both AIR (R=−0.53, P
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