Does long‐term phenytoin have a place in Dravet syndrome?

Autor:	George A. Zographos, Sophie J. Russ‐Hall, Ingrid E. Scheffer
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Zdroj:	Annals of Clinical and Translational Neurology, Vol 9, Iss 12, Pp 2036-2040 (2022)
Druh dokumentu:	article
ISSN:	2328-9503
DOI:	10.1002/acn3.51684
Popis:	Abstract Anti‐seizure medications that block sodium channels are generally considered contraindicated in Dravet syndrome. There is, however, considerable debate about the sodium‐channel blocker phenytoin, which is often used for status epilepticus, a frequent feature of Dravet syndrome. We describe four patients with Dravet syndrome in whom long‐term phenytoin therapy reduced seizure frequency and duration. In two patients, phenytoin produced prolonged periods without status epilepticus for the first time. Attempting to wean phenytoin in all patients after 1 to 20 years of use resulted in seizure exacerbation. Reintroducing phenytoin improved seizure control, suggesting phenytoin is beneficial in some patients with Dravet syndrome.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/d8b97245aba84ca8b253da6d65cb508f Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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