| Autor: |
Konstantin H. Kostov, Hrisimir Kostov, Pål Gunnar Larsson, Oliver Henning, Kari Modalsli Aaberg, Arild Egge, Jukka Peltola, Morten Ingvar Lossius |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Epilepsia Open, Vol 9, Iss 2, Pp 704-716 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2470-9239 |
| DOI: |
10.1002/epi4.12908 |
| Popis: |
Abstract Objective Evaluate the long‐term efficacy of vagus nerve stimulation (VNS) in patients with developmental and epileptic encephalopathies (DEE) compared with epilepsy patients without intellectual disability (ID). Methods Long‐term outcomes from a Norwegian VNS quality registry are reported in 105 patients with DEEs (Lennox–Gastaut syndrome [LGS] n = 62; Dravet n = 16; Rett n = 9; other syndromes n = 18) were compared with 212 epilepsy patients without ID, with median follow‐up of 88 and 72 months, respectively. Total seizure reduction was evaluated at 6, 12, 24, 36, and 60 months. Effect on different seizure types was evaluated at baseline and last observation carried forward (LOCF). Results Median monthly seizure frequency at LOCF was reduced by 42.2% (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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