Simian T-Lymphotropic Virus Diversity among Nonhuman Primates, Cameroon
| Autor: | David M. Sintasath, Nathan D. Wolfe, Matthew LeBreton, Hongwei Jia, Albert D. Garcia, Joseph Le Doux Diffo, Ubald Tamoufe, Jean K. Carr, Thomas M. Folks, Eitel Mpoudi-Ngole, Donald S. Burke, Walid Heneine, William M. Switzer |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Emerging Infectious Diseases, Vol 15, Iss 2, Pp 175-184 (2009) |
| Druh dokumentu: | article |
| ISSN: | 1080-6040 1080-6059 |
| DOI: | 10.3201/eid1502.080584 |
| Popis: | Cross-species transmission of retroviruses is common in Cameroon. To determine risk for simian T-cell lymphotropic virus (STLV) transmission from nonhuman primates to hunters, we examined 170 hunter-collected dried blood spots (DBS) from 12 species for STLV. PCR with generic tax and group-specific long terminal repeat primers showed that 12 (7%) specimens from 4 nonhuman primate species were infected with STLV. Phylogenetic analyses showed broad diversity of STLV, including novel STLV-1 and STLV-3 sequences and a highly divergent STLV-3 subtype found in Cercopithecus mona and C. nictitans monkeys. Screening of peripheral blood mononuclear cell DNA from 63 HTLV-seroreactive, PCR-negative hunters did not identify human infections with this divergent STLV-3. Therefore, hunter-collected DBS can effectively capture STLV diversity at the point where pathogen spillover occurs. Broad screening using this relatively easy collection strategy has potential for large-scale monitoring of retrovirus cross-species transmission among highly exposed human populations. |
| Databáze: | Directory of Open Access Journals |
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