Brain Linac-Based Radiation Therapy: 'Test Drive' of New Immobilization Solution and Surface Guided Radiation Therapy

Autor: Fabiana Gregucci, Ilaria Bonaparte, Alessia Surgo, Morena Caliandro, Roberta Carbonara, Maria Paola Ciliberti, Alberto Aga, Francesco Berloco, Marina De Masi, Christian De Pascali, Federica Fragnoli, Chiara Indellicati, Rosalinda Parabita, Giuseppe Sanfrancesco, Luciana Branà, Annarita Ciocia, Domenico Curci, Pietro Guida, Alba Fiorentino
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Personalized Medicine, Vol 11, Iss 12, p 1351 (2021)
Druh dokumentu: article
ISSN: 11121351
2075-4426
DOI: 10.3390/jpm11121351
Popis: Aim: To test inter-fraction reproducibility, intrafraction stability, technician aspects, and patient/physician’s comfort of a dedicated immobilization solution for Brain Linac-based radiation therapy (RT). Methods: A pitch-enabled head positioner with an open-face mask were used and, to evaluate inter- and intrafraction variations, 1–3 Cone-Beam Computed Tomography (CBCT) were performed. Surface Guided Radiation Therapy (SGRT) was used to evaluate intrafraction variations at 3 time points: initial (i), final (f), and monitoring (m) (before, end, and during RT). Data regarding technician mask aspect were collected. Results: Between October 2019 and April 2020, 69 patients with brain disease were treated: 45 received stereotactic RT and 24 conventional RT; 556 treatment sessions and 863 CBCT’s were performed. Inter-fraction CBCT mean values were longitudinally 0.9 mm, laterally 0.8 mm, vertically 1.1 mm, roll 0.58°, pitch 0.59°, yaw 0.67°. Intrafraction CBCT mean values were longitudinally 0.3 mm, laterally 0.3 mm, vertically 0.4 mm, roll 0.22°, pitch 0.33°, yaw 0.24°. SGRT intrafraction mean values were: i_, m_, f_ longitudinally 0.09 mm, 0.45 mm, 0.31 mm; i_, m_, f_ laterally 0.07 mm, 0.36 mm, 0.20 mm; i_, m_, f_ vertically 0.06 mm, 0.31 mm, 0.22 mm; i_, m_, f_ roll 0.025°, 0.208°, 0.118°; i_, m_, f_ pitch 0.036°, 0.307°, 0.194°; i_, m_, f_ yaw 0.039°, 0.274°, 0.189°. Conclusions: This immobilization solution is reproducible and stable. Combining CBCT and SGRT data confirm that 1 mm CTV-PTV margin for Linac-based SRT was adequate. Using open-face mask and SGRT, for conventional RT, radiological imaging could be omitted.
Databáze: Directory of Open Access Journals
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