| Autor: |
Yuri F. Rego, Cleiton M. da Silva, Daniel L. da Silva, Jeferson G. da Silva, Ana Lúcia T.G. Ruiz, João E. de Carvalho, Sergio A. Fernandes, Ângelo de Fátima |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 4065-4073 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1878-5352 |
| DOI: |
10.1016/j.arabjc.2016.04.007 |
| Popis: |
Fourteen phthalazine-triones bearing different substituents at C-4 position were synthesized through multicomponent reactions (MCR) by using phthalhydrazide, dimedone and diferent aldehydes as starting materials, p-sulfonic acid calix[4]arene as catalyst and ethyl lactate as solvent under microwave irradiation. Compounds 7–16 were obtained in excellent to moderate yields (94–51%) in only 10 min of reaction using this methodology. The antiproliferative activity against cancer cells was disclosed, for the first time, for synthesized compounds. The capacity of all compounds to inhibit cancer cells growth was dependent on the histological origin of cells. Compound 20 was active against more than one strain. Keywords: Catalysis, Green chemistry, Microwave assisted synthesis, Antiproliferative activity, p-Sulfonic acid calix[4]arene |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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