| Autor: |
Antônio Barros de Souza, Jacqueline Cosmo Andrade Pinheiro, Juliete Bezerra Soares, José Ismael Feitosa de Araújo, Sandra Maria Barbosa de Araújo, Francisco Lucas Alves Batista, Kalina Kelma Oliveira de Sousa, Saulo Relison Tintino, Isaac Moura Araujo, Francisco Ernani Alves Magalhães, Laura Hévila Inocencio Leite, Francisco Roberto de Azevedo |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Fish and Shellfish Immunology Reports, Vol 5, Iss , Pp 100108- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2667-0119 |
| DOI: |
10.1016/j.fsirep.2023.100108 |
| Popis: |
Ziziphus joazeiro Mart. is an endemic plant of the Caatinga that presents a great socioeconomic importance for the Northeast and Semiarid Region of Brazil. In view of this, this study aimed to evaluate the antibacterial activity and anxiolytic-like effects of Ziziphus joazeiro Mart leaves in adult zebrafish (Danio rerio). The characterization of the main classes of metabolites was performed through chemical reactions. The antibacterial and antibiotic potentiating activity was evaluated by broth microdilution assays. The 96 h acute toxicity, open field test and anxiety models test was evaluated in vivo on adult zebrafish. The results obtained in the phytochemical prospection evidenced the presence of flobabenic tannins, leucoanthocyanidins, flavonois, flavonones, catechins, alkaloids, steroids, and triterpenoids. EEFZJ did not show antibacterial activity for all microorganism tested (MIC ≥ 1024 µg/mL), but reduced the concentration required for bacterial growth inhibition in combination with gentamicin and norfloxacin against multidrug-resistant strains of S. aureus (SA10) and E. coli (EC06), exhibiting synergistic effect with these antibiotics (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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