Evaluation of cardiac remodeling in pediatric chronic kidney disease by cardiovascular magnetic resonance

Autor: Sisi Song, Linjun Xie, Huayan Xu, Ke Xu, Hang Fu, Lu Zhang, Ruilai Hou, Yuhong Tao, Yingkun Guo
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-11 (2024)
Druh dokumentu: article
ISSN: 1471-2261
DOI: 10.1186/s12872-024-04179-1
Popis: Abstract Background Children with chronic kidney disease (CKD) are at high risk of cardiovascular disease. Cardiovascular magnetic resonance (CMR) is the reference method for assessing cardiac remodeling. To our knowledge, no study has reported a comprehensive analysis of left ventricular(LV) cardiac remodeling using CMR in different stages of pediatric CKD. This prospective case-control study aimed to investigate cardiac remodeling in pediatric CKD, using CMR, and determine its relationship with risk factors. Method CMR was performed in 124 children with CKD and 50 controls. The cardiac remodeling parameters included left ventricular mass index (LVMI), LV remodeling index (LVRI), and LV wall thickness. Univariable and multivariable analyses were performed to assess the cardiac remodeling risk factors. Results Cardiac remodeling was observed in 35.5% (44/124) of children with CKD. The LVMI, LVRI, and LV wall thickness were higher in advanced stages of CKD (P
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