Effect of Sclerorhachis leptoclada hydroalcoholic extract on glucose and cholesterol levels, triglyceride, as well as Serum HDL and LDL in male diabetic rats
| Autor: | Omid Ghafoorian Eshghi, Maryam Tehranipour, Javad Baharara, Nastaran Amintaheri |
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| Jazyk: | perština |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | مجله دانشگاه علوم پزشکی بیرجند, Vol 27, Iss 4, Pp 344-354 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1607-2197 2423-6152 |
| Popis: | Background and Aims: Diabetes is a metabolic disorder in the body. Sclerorhachis leptoclada belongs to the chicory family and is used for the treatment of AIDS and cancer due to the antioxidant compounds in the root. Therefore, this study investigated the effect of hydroalcoholic extract of Sclerorhachis leptoclada on glucose, cholesterol, triglyceride, high density lipoprotein (HDL), and low density lipoprotein (LDL) levels in diabetic rats. Materials and Methods: This experimental study included 60 male Wistar rats that were randomly divided into 10 groups of six animals per group, including control group, treatment groups 1, 2, and 3 (healthy, treated with 150 mg/kg and 300, and 600 extracts), diabetic control group, experimental groups 1, 2, and 3 (diabetic, treated with 150 mg/kg and 300 and 600 doses of extracts), positive control group (diabetic+glibenclamide), and healthy group (healthy+glibenclamide). Blood samples were taken from the rats after one month of gavage, and the measurement of glucose, urea, creatinine, and albumin levels were conducted in this study. Furthermore, a comparison was made between the effect of hydroalcoholic extract of Sclerorhachis leptoclada and the glibenclamide (a common medicin). Eventually, the results obtained from the groups were compared using t-test and ANOVA. Results: The results showed that the administration of hydroalcoholic extract of Sclerorhachis leptoclada could significantly reduce glucose levels in the experimental groups (diabetic+extract at doses of 150, 300, 600), compared to the diabetic group (P |
| Databáze: | Directory of Open Access Journals |
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