Association between potassium supplementation and the occurrence of acute kidney injury in patients with hypokalemia administered liposomal amphotericin B: a nationwide observational study

Autor: Yuki Ota, Yoko Obata, Takahiro Takazono, Masato Tashiro, Tomotaro Wakamura, Akinori Takahashi, Yui Shiozawa, Taiga Miyazaki, Tomoya Nishino, Koichi Izumikawa
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: BMC Nephrology, Vol 22, Iss 1, Pp 1-12 (2021)
Druh dokumentu: article
ISSN: 1471-2369
DOI: 10.1186/s12882-021-02450-7
Popis: Abstract Background Hypokalemia and acute kidney injury (AKI) occur in patients administered liposomal amphotericin B (L-AMB), a wide-spectrum anti-fungicidal drug. However, the association between potassium supplementation and the occurrence of AKI in patients with hypokalemia who were administered L-AMB is not well understood. Methods Using nationwide claims data and laboratory data, the occurrence of AKI during L-AMB treatment was retrospectively compared between patients with hypokalemia who were or were not supplemented with potassium and between those adequately or inadequately supplemented with potassium (serum potassium levels corrected to ≥3.5 mEq/L or remained
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