Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial

Autor: Su-Jin Jung, Eun-Soo Jung, Eun-Kyung Choi, Hong-Sig Sin, Ki-Chan Ha, Soo-Wan Chae
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: BMC Complementary and Alternative Medicine, Vol 19, Iss 1, Pp 1-8 (2019)
Druh dokumentu: article
ISSN: 1472-6882
DOI: 10.1186/s12906-019-2483-y
Popis: Abstract Background Cordyceps is a traditional Chinese herb that produces various biopharmaceutical effects, including immune-enhancing effects. In this study, we prepared a Cordyceps mycelium culture extract (Paecilomyces hepiali, CBG-CS-2) to confirm its efficacy in enhancing the immune system and to evaluate its safety in healthy adults. Methods Healthy adults were divided into the intervention group (n = 39), who were given 1.68 g/day of CBG-CS-2 in capsules, and the control group (n = 40) for 8 weeks. The activities of natural killer (NK) cells and serum levels of monocyte-derived mediators were assessed initially for a baseline measurement and after 8 wks. Results The CBG-CS-2 group showed a significant 38.8 ± 17.6% enhancement from the baseline of NK cell cytotoxic activity relative to the placebo group after the administration of the capsules for 8 wks. (P
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