Efeitos da semicarbazida no esqueleto de ratos Wistar em crescimento
| Autor: | A. Ramos, A. Pereira, A.S. Cabrita, F. Capela e Silva |
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| Jazyk: | English<br />Portuguese |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Vol 64, Iss 2, Pp 499-504 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1678-4162 0102-0935 |
| DOI: | 10.1590/S0102-09352012000200035 |
| Popis: | The effects of semicarbazide hydrochloride on skeletal tissues were evaluated using Wistar rats. In the animals submitted to the administration of semicarbazide, radiological examination showed bone and articular alterations with growth plates enlargement. Histological exams showed irregular patterns and proliferation of chondrocytes and excessive accumulation of extracellular matrix. Immunohistochemical exams showed PCNA positive reaction in pre- and hypertrofic chondrocytes. These results confirm that semicarbazide induces important changes in skeletal tissues and that has potential utility in experimental osteolathryrism |
| Databáze: | Directory of Open Access Journals |
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