Novel biomarkers of ciliary extracellular vesicles interact with ciliopathy and Alzheimer’s associated proteins

Autor:	Ashraf M. Mohieldin, Amal Alachkar, John Yates, Surya M. Nauli
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	ciliary extracellular vesicles cytosolic extracellular vesicles exosome ectosome primary cilia ciliopathy disorders alzheimer disease neurodegenerative disorders bioinformatic proteomics biomarkers Biology (General) QH301-705.5
Zdroj:	Communicative & Integrative Biology, Vol 14, Iss 1, Pp 264-269 (2021)
Druh dokumentu:	article
ISSN:	1942-0889 19420889
DOI:	10.1080/19420889.2021.2017099
Popis:	Ciliary extracellular vesicles (ciEVs), released from primary cilia, contain functional proteins that play an important role in cilia structure and functions. We have recently shown that ciEVs and cytosolic extracellular vesicles (cyEVs) have unique and distinct biomarkers. While ciEV biomarkers have shown some interactions with known ciliary proteins, little is known about the interaction of ciEV proteins with proteins involved in ciliopathy and neurodegenerative disorders. Here, we reveal for the first time the protein-protein interaction (PPI) between the top five ciEVs biomarkers with ciliopathy and Alzheimer disease (AD) proteins. These results support the growing evidence of the critical physiological roles of cilia in neurodegenerative disorders.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/8b67b6f930f24ebab758a27782ece0e5 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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