Occupational and community risk of SARS-CoV-2 infection among employees of a long-term care facility: an observational study

Autor: Lauriane Lenggenhager, Romain Martischang, Julien Sauser, Monica Perez, Laure Vieux, Christophe Graf, Samuel Cordey, Florian Laubscher, Tomás Robalo Nunes, Walter Zingg, Anne Cori, Stephan Harbarth, Mohamed Abbas
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Antimicrobial Resistance and Infection Control, Vol 11, Iss 1, Pp 1-8 (2022)
Druh dokumentu: article
ISSN: 2047-2994
DOI: 10.1186/s13756-022-01092-0
Popis: Abstract Background We investigated the contribution of both occupational and community exposure for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among employees of a university-affiliated long-term care facility (LTCF), during the 1st pandemic wave in Switzerland (March–June 2020). Methods We performed a nested analysis of a seroprevalence study among all volunteering LTCF staff to determine community and nosocomial risk factors for SARS-CoV-2 seropositivity using modified Poison regression. We also combined epidemiological and genetic sequencing data from a coronavirus disease 2019 (COVID-19) outbreak investigation in a LTCF ward to infer transmission dynamics and acquisition routes of SARS-CoV-2, and evaluated strain relatedness using a maximum likelihood phylogenetic tree. Results Among 285 LTCF employees, 176 participated in the seroprevalence study, of whom 30 (17%) were seropositive for SARS-CoV-2. Most (141/176, 80%) were healthcare workers (HCWs). Risk factors for seropositivity included exposure to a COVID-19 inpatient (adjusted prevalence ratio [aPR] 2.6; 95% CI 0.9–8.1) and community contact with a COVID-19 case (aPR 1.7; 95% CI 0.8–3.5). Among 18 employees included in the outbreak investigation, the outbreak reconstruction suggests 4 likely importation events by HCWs with secondary transmissions to other HCWs and patients. Conclusions These two complementary epidemiologic and molecular approaches suggest a substantial contribution of both occupational and community exposures to COVID-19 risk among HCWs in LTCFs. These data may help to better assess the importance of occupational health hazards and related legal implications during the COVID-19 pandemic.
Databáze: Directory of Open Access Journals
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