| Autor: |
Özge Gündüz, Deepak Modi, Raquel Duarte |
| Jazyk: |
English<br />Turkish |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Turkderm Turkish Archives of Dermatology and Venereology, Vol 55, Iss 2, Pp 56-60 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2651-5164 |
| DOI: |
10.4274/turkderm.galenos.2020.23326 |
| Popis: |
Atopic dermatitis (AD) is a chronic skin disease affecting mainly children with an increasing prevalence worldwide. AD is a complex trait resulting from genetic predisposition, skin barrier dysfunction, immune dysregulation, and environmental factors. The major risk factors for AD are a family history of atopy (eczema, asthma, or allergic rhinitis) and the loss-of-function mutations in the filaggrin (FLG) gene. This review highlights the role of the genetic abnormalities identified in AD, from the susceptibility loci in genome-wide associations to epigenetic studies. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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