BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency

Autor: Feixia Wang, Yifeng Liu, Feida Ni, Jiani Jin, Yiqing Wu, Yun Huang, Xiaohang Ye, Xilin Shen, Yue Ying, Jianhua Chen, Ruixue Chen, Yanye Zhang, Xiao Sun, Siwen Wang, Xiao Xu, Chuan Chen, Jiansheng Guo, Dan Zhang
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-33323-8
Popis: Primary ovarian insufficiency (POI) is a clinical syndrome of ovarian dysfunction that results in infertility. Here they show that BCN1 mutation results in premature ovarian follicle activation and atresia through dysregulation of ferroptosis.
Databáze: Directory of Open Access Journals