Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells

Autor: Lara Ribeiro-Parenti, Anne-Charlotte Jarry, Jean-Baptiste Cavin, Alexandra Willemetz, Johanne Le Beyec, Aurélie Sannier, Samira Benadda, Anne-Laure Pelletier, Muriel Hourseau, Thibaut Léger, Bastien Morlet, Anne Couvelard, Younes Anini, Simon Msika, Jean-Pierre Marmuse, Sévérine Ledoux, Maude Le Gall, André Bado
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-20301-1
Popis: GLP-1 is a gastrointestinal peptide that regulates gastric acid secretion and emptying, and due to the rapid degradation of intestinally secreted GLP-1 local gastric production has been suggested. Here the authors report the presence of GLP-1 expressing cells in the rat and human stomach, which contribute to the circulating GLP-1 levels and are affected by weight loss surgeries.
Databáze: Directory of Open Access Journals