CLINICAL AND IMMUNOLOGICAL ASPECTS OF CHRONIC OBSTRUCTIVE LUNG DISEASE
Autor: | T. O. Kostrova, G. V. Lisachenko, A. V. Shabaldin |
---|---|
Jazyk: | ruština |
Rok vydání: | 2014 |
Předmět: | |
Zdroj: | Медицинская иммунология, Vol 12, Iss 3, Pp 207-212 (2014) |
Druh dokumentu: | article |
ISSN: | 1563-0625 2313-741X |
DOI: | 10.15789/1563-0625-2010-3-207-212 |
Popis: | On the basis of clinical observations in eighty-eight persons with chronic obstructive lung disease (COPD) at mild, moderate and severe clinical stages, and twenty-two persons with chronic bronchitis in recurrence phase, we have revealed some features of immune disturbances in various clinical forms of ventilation disorders. A direct dependence between severity of main disorder and the degree of cellular immune deficiency was shown, manifesting as low expression of early and late activation markers (resp., СD25 and HLA-DR). We have revealed a coupling between severity of clinical manifestations, degree of ventilation problems, and disturbances of immune response in COPD patients. This immune response depends on the level of T-helpers, expression of early and late activation markers. |
Databáze: | Directory of Open Access Journals |
Externí odkaz: |