Synthesis and Characterization of Heterocyclic Compounds Derived From 4- Hydroxy and 4-Amino Acetophenone
| Autor: | Nisreen H. Karam, Jumbad H. Tomma, Ammar H. AL-dujaili |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Ibn Al-Haitham Journal for Pure and Applied Sciences, Vol 26, Iss 3 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1609-4042 2521-3407 |
| Popis: | Two series of Schiff Bases [VI]n and thiazolidin-4-one derivatives[VII]n were synthesized by many steps starting from cyclization of 4- hydroxyacetophenon with thiourea in iodine to yield 1,3-thiazole compound which was reacted with pentoxy bromide in anhydrous potassium carbonate to converted compound[II] and this reacted with Phenol to yield azo compound[III]. The azo compound reacted with ethyl chloro acetate in basic medium to get a new easter compound[IV] which is converted to their acid hydrazid[V]. The later compound condensation with n-alkoxy benzaldehyde to give new Schiff bases[VI]n . Imine group undergoes addition cyclization with thioglycolic acid to get thiazolidinone compounds[VII]n .Also, two new series of Schiff Bases [XII]n and their thiazolidin-4-one derivatives[XIII]n were synthesized by using the same steps given for synthesis Schiff bases [VI]n and thiazoidinone [VII]n except using 4- aminoacetophenon instead of 4- hydroxyacetophenon(see scheme 2) .The synthesized compounds were characterized by melting points , FTIR ,C.H.N.S analysis , 1HNMR and Mass spectroscopy (of some of them) |
| Databáze: | Directory of Open Access Journals |
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