A combination DNA vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against Leishmania mexicana

Autor:	Chalé-balboa W.G., Mut-Martin M., Ramirez-Sierra M.J., Garcia-Miss M.R., Dumonteil E.
Jazyk:	angličtina
Rok vydání:	2009
Předmět:	leishmaniasis vaccine hamster Infectious and parasitic diseases RC109-216
Zdroj:	Parasite, Vol 16, Iss 3, Pp 227-230 (2009)
Druh dokumentu:	article
ISSN:	1252-607X 1776-1042
DOI:	10.1051/parasite/2009163227
Popis:	Leishmaniasis is a group of diseases caused by protozoan parasites of the Leishmania genus. Previous studies have shown that a DNA vaccine encoding Leishmania donovani antigen nucleoside hydrolase 36 and L. mexicana glycoprotein 63 is protective in mice. We investigated here the efficacy of this DNA vaccine to induce protection in golden hamsters. Male hamsters were more susceptible to infection by Leishmania mexicana than females. Following immunization with two doses of the DNA vaccine, only females resulted protected while males developed normal lesions.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/8b30485b918947699b365c20afcbf4ea Zobrazit plný text záznamu View record in DOAJ