| Autor: |
Brittany Butts, PhD, Mustafa I. Ahmed, MD, Navkaranbir S. Bajaj, MD, MPH, Pamela Cox Powell, MS, Betty Pat, PhD, Silvio Litovsky, MD, Himanshu Gupta, MD, Steven G. Lloyd, MD, Thomas S. Denney, PhD, Xiaoxia Zhang, PhD, Inmaculada Aban, PhD, Sakthivel Sadayappan, PhD, MBA, James W. McNamara, PhD, Michael J. Watson, PhD, Carlos M. Ferrario, MD, James F. Collawn, PhD, Clifton Lewis, MD, James E. Davies, MD, Louis J. Dell’Italia, MD |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
JACC: Basic to Translational Science, Vol 5, Iss 2, Pp 109-122 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2452-302X |
| DOI: |
10.1016/j.jacbts.2019.11.006 |
| Popis: |
Summary: Increasing left atrial (LA) size predicts outcomes in patients with isolated mitral regurgitation (MR). Chymase is plentiful in the human heart and affects extracellular matrix remodeling. Chymase activation correlates to LA fibrosis, LA enlargement, and a decreased total LA emptying fraction in addition to having a potential intracellular role in mediating myofibrillar breakdown in LA myocytes. Because of the unreliability of the left ventricular ejection fraction in predicting outcomes in MR, LA size and the total LA emptying fraction may be more suitable indicators for timing of surgical intervention. Key Words: chymase, fibrosis, left atrium, left ventricle, mitral regurgitation, mitral valve |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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