| Autor: |
Marco Maugeri, Muhammad Nawaz, Alexandros Papadimitriou, Annelie Angerfors, Alessandro Camponeschi, Manli Na, Mikko Hölttä, Pia Skantze, Svante Johansson, Martina Sundqvist, Johnny Lindquist, Tomas Kjellman, Inga-Lill Mårtensson, Tao Jin, Per Sunnerhagen, Sofia Östman, Lennart Lindfors, Hadi Valadi |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-019-12275-6 |
| Popis: |
Lipid nanoparticles (LNPs) are potential platforms for RNA-based therapeutics, but the fate of LNP-RNAs upon internalization into the cell is unclear. Here, the authors show that LNP-mRNAs and ionizable lipids escape the endosomes and are re-released via extracellular vesicles which could deliver the functional mRNA to other cells. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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