The role of polymorphism in TNF gene promotive area in the development of chronic obstructive pulmonary disease
| Autor: | G. N. Seitova, Ye. B. Bukreeva, S. V. Buykin, O. Yu. Bychkova, Ye. A. Dementyeva, S. V. Nesterovich, V. P. Puzyryov |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2004 |
| Předmět: | |
| Zdroj: | Бюллетень сибирской медицины, Vol 3, Iss 2, Pp 29-34 (2004) |
| Druh dokumentu: | article |
| ISSN: | 1682-0363 1819-3684 |
| DOI: | 10.20538/1682-0363-2004-2-29-34 |
| Popis: | Association of –308G/A-polymorphism of α-tumor necrosis factor (TNF) gene with the development of chronic obstructive pulmonary disease has been investigated in two populations of Tomsk city (Siberian Tatars and Russians). As a result, it has not been marked any genotype distribution deviation of expected in patient groups as well as in control groups at Hardy-Vainberg equilibrium. Statistically significant difference in allele distribution rate at patients with COPD and in control groups has not been found (p > 0,5) including ethnic groups (Russians and Tatars). Differences in genotype distribution at patients and control group have been found for Tatars due to heterosive carrier (AG) prevalence at patients (p < 0,05). The obtained data allow to conclude the presence of association of –308G/A-polymorphism of TNF gene with the COPD development at Siberian Tatars. |
| Databáze: | Directory of Open Access Journals |
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