O uso do forno de microondas na síntese orgânica em fase sólida The use of microwave ovens in solid-phase organic synthesis

Autor: Cedric Stephan Graebin, Vera Lucia Eifler-Lima
Jazyk: English<br />Spanish; Castilian<br />Portuguese
Rok vydání: 2005
Předmět:
Zdroj: Química Nova, Vol 28, Iss 1, Pp 73-76 (2005)
Druh dokumentu: article
ISSN: 0100-4042
1678-7064
DOI: 10.1590/S0100-40422005000100015
Popis: Solid-phase organic synthesis (SPOS) has been considered the main strategy for the construction of combinatorial libraries, because its simplicity leads to faster synthetic procedures. In addition to that, a series of reports in the specialized literature show great advantages in the use of microwave activation, when compared to classical heating, for instance: shorter reaction times, in some cases from several hours to a few minutes, increase of selectivity and product yields, energy economy and reduction and/or elimination of solvent. This review describes the use of microwave ovens/reactors in solid phase organic synthesis, describing the advantages, equipment and reactions using both techniques.
Databáze: Directory of Open Access Journals