Autor: |
Hiroyuki Shimada, Keitaro Makino, Takashi Kato, Kengo Ito |
Jazyk: |
angličtina |
Rok vydání: |
2023 |
Předmět: |
|
Zdroj: |
BMC Geriatrics, Vol 23, Iss 1, Pp 1-5 (2023) |
Druh dokumentu: |
article |
ISSN: |
1471-2318 |
DOI: |
10.1186/s12877-023-03918-x |
Popis: |
Abstract Background This study aimed to identify the appropriate computer-based cognitive tests and cut-off values for estimating amyloid burden in preclinical Alzheimer’s disease drug trials. Methods Data from 103 older individuals, who underwent 18F-florbetapir positron emission tomography and cognitive testing, were analyzed. Cognitive tests evaluated word list memory (immediate recognition and delayed recall), attention (Trail Making Test-part A), executive function (Trail Making Test-Part B), and processing speed (Digit Symbol Substitution Test [DSST]). Results The Aβ burden was significantly associated with word list memory (odds ratio [OR] = 0.42, 95% confidence interval [CI], 0.19–0.91) and DSST (OR = 0.35; 95% CI, 0.14–0.85). Positive predictive value and number needed to screen at a cut-off of 1.5 SD were better for word list memory and DSST among predictive values. Conclusions The computer-based memory and processing speed tests have the potential to reduce failure rates while screening individuals with Aβ accumulation in community settings. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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