| Autor: |
Fadwa Albalawi, Fadwa M AlKhulaifi, Jameel Al-Tamimi, Lamjed Mansour, Yusra Tashkandy, Suliman Yousef Alomar |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of King Saud University: Science, Vol 35, Iss 6, Pp 102723- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1018-3647 |
| DOI: |
10.1016/j.jksus.2023.102723 |
| Popis: |
Objective: Natural Killer cells activation depends on the interaction with killer cell immunoglobin-like receptors (KIRs), which bind the peptide-binding region of several class-I Human Leukocyte Antigens (HLA class-I). In addition, KIR and HLA loci are highly polymorphic and display significant variation between individuals. Methods: We attempted to investigate the association of 16 KIR complexes and the HLA-C1 and C2 ligands to the genetic predisposition and development of Acute Lymphoblastic leukemia (AML) in Saudi Arabian patients. We genotyped 16 KIR genes for 100 patients with Acute Lymphoblastic leukemia and 114 healthy controls, and all samples were considered for evaluating combined KIR-HLA C1/C2 associations. Results: KIR genotype frequency differed significantly between AML patients and healthy controls. KIR2DL1, KIR2DL5, and KIR2DS2 increased significantly in patients than in controls. The 2DL5 gene contributed to the highest risk of AML (OR = 2.9906, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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