Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model.

Autor: Soeren Erik Pischke, Siv Hestenes, Harald Thidemann Johansen, Hilde Fure, Jan Frederik Bugge, Andreas Espinoza, Helge Skulstad, Thor Edvardsen, Erik Fosse, Tom Eirik Mollnes, Per Steinar Halvorsen, Erik Waage Nielsen
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: PLoS ONE, Vol 14, Iss 6, p e0218624 (2019)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0218624
Popis: INTRODUCTION:Right ventricular (RV) myocardial dysfunction is a common feature in septic shock. It can worsen outcome, but the etiology is poorly understood. Pulmonary artery hypertension (PAH) plays a part in the pathogenesis of the right heart dysfunction in sepsis but its importance is unknown. In pigs, PAH in sepsis is substantial and the translational value of porcine sepsis models therefore questioned. We hypothesized that porcine sepsis causes a myocardial inflammatory response which leads to myocardial dysfunction independent of PAH. MATERIALS AND METHODS:Sepsis was induced by Escherichia coli-infusion in 10 pigs resulting in PAH and increased right ventricular pressure (RVP). The same degree of RVP was achieved by external pulmonary artery banding (PAB) in a consecutive series of 6 animals. RESULTS:Sepsis, but not PAB, led to increase in endothelial damage marker PAI-1 and cytokines TNF and IL-6 (all p
Databáze: Directory of Open Access Journals
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