Research and application of single-cell sequencing in tumor heterogeneity and drug resistance of circulating tumor cells

Autor: Zhe Dai, Xu-yu Gu, Shou-yan Xiang, Dan-dan Gong, Chang-feng Man, Yu Fan
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Biomarker Research, Vol 8, Iss 1, Pp 1-8 (2020)
Druh dokumentu: article
ISSN: 2050-7771
DOI: 10.1186/s40364-020-00240-1
Popis: Abstract Malignant tumor is a largely harmful disease worldwide. The cure rate of malignant tumors increases with the continuous discovery of anti-tumor drugs and the optimisation of chemotherapy options. However, drug resistance of tumor cells remains a massive obstacle in the treatment of anti-tumor drugs. The heterogeneity of malignant tumors makes studying it further difficult for us. In recent years, using single-cell sequencing technology to study and analyse circulating tumor cells can avoid the interference of tumor heterogeneity and provide a new perspective for us to understand tumor drug resistance.
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