Rate of premalignant and malignant endometrial lesion in 'low-risk' premenopausal women with abnormal uterine bleeding undergoing endometrial biopsy
| Autor: | Sangam Jha, Akanksha Singh, Hemali Heidi Sinha, Poonam Bhadani, Monika Anant, Mukta Agarwal |
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| Jazyk: | English<br />Korean |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Obstetrics & Gynecology Science, Vol 64, Iss 6, Pp 517-523 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2287-8572 2287-8580 |
| DOI: | 10.5468/ogs.21150 |
| Popis: | Objective To determine the incidence of endometrial hyperplasia and endometrial cancer (EH/EC) in low-risk premenopausal women with abnormal uterine bleeding (AUB) undergoing endometrial biopsy and to build a predictive model that includes clinical variables for predicting EH/EC in these women. Methods This retrospective study was conducted between January 2015 and March 2020. All premenopausal women aged 25 kg/m2 (odds ratio [OR], 4.4705), age >40 years (OR, 1.14), endometrial thickness (ET) >13 mm (OR, 2.59), and hypothyroidism (OR, 1.35) were significantly associated with EH/ EC. Considering the pretest probability for an EH/EC of 4.7%, this prediction model with a likelihood ratio of 14.2% demonstrated a post-test probability of 41% in the presence of the above-mentioned variables. Conclusion The risk of EH/EC was lower in low-risk premenopausal women with AUB. However, premenopausal women with IMB aged >40 years, hypothyroidism, BMI >25 kg/m2, and thickened endometrium (ET >13 mm) are at high risk of EH/EC; therefore, endometrial biopsy should be considered early in their management plan. |
| Databáze: | Directory of Open Access Journals |
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