Clinical Outcomes of Dose-Escalated Hypofractionated External Beam Radiation Therapy (5 Gy × 5 Fractions) for Spine Metastasis

Autor: Jacob Y. Shin, MD, Noah J. Mathis, BS, Neil Ari Wijetunga, MD, PhD, Divya Yerramilli, MD, Daniel S. Higginson, MD, Adam M. Schmitt, MD, Daniel R. Gomez, MD, Yoshiya J. Yamada, MD, Jonathan T. Yang, MD, PhD
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Advances in Radiation Oncology, Vol 7, Iss 4, Pp 100906- (2022)
Druh dokumentu: article
ISSN: 2452-1094
DOI: 10.1016/j.adro.2022.100906
Popis: Purpose: The objective of this study was to determine the toxicities and outcomes of patients with spinal metastasis treated with external beam radiation therapy (EBRT) to 25 Gy in 5 fractions. Methods and Materials: Data were extracted from an institutional tumor registry for patients with spinal metastasis who were treated with EBRT to 25 Gy in 5 fractions to their spinal lesion(s). Cox regression and Kaplan-Meier analyses to determine local control and overall survival (OS) were employed. Results: Seventy-five patients with 86 total treated spinal metastatic tumors were identified. The median follow-up was 7 months. The median age was 66 years. Fifty-six patients (75.7%) experienced partial or complete pain relief for a median duration of 6 months (range, 1-33). Fifty-one (59.3%) cases were planned using intensity modulated radiation therapy while 19 (22.1%) employed 3-dimensional conformal radiation therapy and 16 (18.6%) cases used nonconformal radiation technique. Greater than 90% of cases had a point dose maximum to the spinal cord/cauda equina
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